Daira Read, highlight, and take notes, across web, tablet, and phone. Oxford University Press is a department of korff University of Oxford. Sequence similarity is a powerful tool for discovering biological function. This is a book that any biologist should own. Unfortunately, these kinds of searches are computationally intensive and often represent bottlenecks in sequence analysis pipelines.
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Tazahn It offers biologists, computational biology students, and bioinformatics professionals a clear understanding of BLAST as well as the science it supports. It is one of the most important software packages used in sequence analysis and bioinformatics. This is a book that any biologist should own. His goal in life is to follow genomes, wherever they happen to take him. Louis where he spends his days and nights using BLAST to answer important biological and phylogenetic questions in plants.
Some of the topics covered include: Just as the ancient Greeks used comparative anatomy to understand the human body and linguists used the Rosetta stone to decipher Egyptian hieroglyphs, today we can use comparative sequence analysis to understand genomes. The COP9 signalosome influences the epigenetic landscape of Arabidopsis thaliana. Skickas inom vardagar. This book shows you how to move beyond the default parameters, get specific answers using BLAST, and how to interpret your results.
Joseph Bedell received his B. However, high scoring alignments are relatively resistant to such changes in parameters, and this fact makes it possible to use a serial strategy where a fast, insensitive search is used to pre-screen a database for similar sequences, and a slow, sensitive search is used to produce the sequence alignments.
Selected pages Title Page. Email alerts New issue alert. The translating BLAST algorithms are powerful tools for finding protein-coding genes because they identify amino acid similarities in nucleotide sequences.
BLAST is the only book completely devoted to this popular suite of tools. Close mobile search navigation Article navigation. Citing articles via Web of Science Sequence similarity is a powerful tool for discovering biological function. Unfortunately, these kinds of searches are computationally intensive and often represent bottlenecks in sequence analysis pipelines.
After graduation, he joined the Genome Sequencing Center at Washington University, where he pursued post-doctoral studies in computational biology, genome annotation and SNP discovery. Account Options Sign in. Joseph, like his co-authors, completed a post-doc in mammalian gene annotation with Blasr Gish, one of the original developers of BLAST.
BioinformaticsVolume 19, Issue 12, 12 AugustPages —, https: Read, highlight, and take notes, across web, tablet, and phone. He, and the company he works for, make extensive use of BLAST in their gene sequencing and gene discovery efforts.
D from Indiana University. Your research has generated gigabytes of data and now you need to iaj it. Oxford University Press is a department of the University of Oxford. Most 10 Related.
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